https://bradleymonk.com/wiki/index.php?action=history&feed=atom&title=File%3ALu_Nicoll_2009_FIG6.jpg 2026-04-09T17:16:13Z Revision history for this page on the wiki MediaWiki 1.41.0 https://bradleymonk.com/wiki/index.php?title=File:Lu_Nicoll_2009_FIG6.jpg&diff=2755&oldid=prev 2015-03-21T02:12:12Z

<p></p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 19:12, 20 March 2015</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l8">Line 8:</td> <td colspan="2" class="diff-lineno">Line 8:</td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>(E) Models for AMPAR compositions at synaptic and extrasynaptic membranes. At CA1 pyramidal neurons, ∼80% synaptic AMPARs are GluA1A2 heteromers, and ∼16% synaptic AMPARs are GluA2A3 heteromers. On the other hand, ∼95% extrasynaptic AMPARs are GluA1A2 heteromers.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>(E) Models for AMPAR compositions at synaptic and extrasynaptic membranes. At CA1 pyramidal neurons, ∼80% synaptic AMPARs are GluA1A2 heteromers, and ∼16% synaptic AMPARs are GluA2A3 heteromers. On the other hand, ∼95% extrasynaptic AMPARs are GluA1A2 heteromers.</div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>[[Category:Synaptic Plasticity]] [[Category:Journals]]</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>[[Category:Synaptic Plasticity]] [[Category:Journals<ins style="font-weight: bold; text-decoration: none;">]][[Category:Nicoll</ins>]]</div></td></tr> </table>

Bradley Monk https://bradleymonk.com/wiki/index.php?title=File:Lu_Nicoll_2009_FIG6.jpg&diff=2746&oldid=prev 2015-03-21T02:07:26Z

<p></p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 19:07, 20 March 2015</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l1">Line 1:</td> <td colspan="2" class="diff-lineno">Line 1:</td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">{{Article|Lu, Shi, Nicoll|2009|Cell - [http://www.sciencedirect.com/science/article/pii/S0896627309002554 FullText]|19409270|Subunit composition of synaptic AMPA receptors revealed by a single-cell genetic approach}}</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">; Figure 6. </ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">Analysis of Extrasynaptic AMPARs</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">(A) Sample traces of AMPAR currents from OOPs from uninfected control (black) and Cre (green) cells from CA1 pyramidal neurons from various genetic backgrounds. Scale bar, 200 pA, 1 s. The recordings were made from acute hippocampal slices (P13–P17 for ΔGluA2 and P20–P28 for all other genetic backgrounds) from animals injected at P0–P2.</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">(B) I/V curves of AMPAR currents from OOPs. Control, black; Cre, green. Deletion of the GluA2 subunit, but not other subunits, caused strong inward rectification of the evoked current. Bar graph at the bottom shows the RI for each condition (Cnt, 0.85 ± 0.02, n = 8; ΔGluA1, 0.81 ± 0.04, n = 5; p = 0.39; ΔGluA2, 0.09 ± 0.01, n = 6; ∗p &lt; 0.001; ΔGluA3, 0.80 ± 0.03, n = 5; p = 0.22; ΔGluA2A3, 0.10 ± 0.02, n = 6; ∗p &lt; 0.001; ΔGluA1A2, 0.15 ± 0.03, n = 5; ∗p &lt; 0.001).</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">(C) Summary bar graph shows consequences of deletion of respective genes on AMPAR current from OOPs (Cnt, −648.7 ± 45.2 pA, n = 23; ΔGluA1, −35.3 ± 13.1 pA, n = 16, ∗p &lt; 0.001; ΔGluA2, −684.3 ± 92.2 pA, n = 11, p = 0.70; ΔGluA3, −674.2 ± 63.5 pA, n = 13, p = 0.74; ΔGluA2A3, −656.8 ± 76.3 pA, n = 14, p = 0.92; ΔGluA1A3, −2.5 ± 1.0 pA, n = 14, ∗p &lt; 0.001; ΔGluA1A2, −24.1 ± 5.2 pA, n = 25, ∗p &lt; 0.001; ΔGluA1A2A3, −1.01 ± 0.65 pA, n = 8, ∗p &lt; 0.001).</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">(D) Summary bar graph shows consequences of deletion of respective genes on AMPAR EPSCs (percent control: ΔGluA1, 19.4 ± 3.1%, n = 31, ∗p &lt; 0.001; ΔGluA2, 51.7 ± 3.8%, n = 86, ∗p &lt; 0.001; ΔGluA3, 83.8 ± 1.0%, n = 19, ∗p &lt; 0.05; ΔGluA2A3, 42.8 ± 5.2%, n = 14, ∗p &lt; 0.001; ΔGluA1A3, 12.1 ± 2.4%, n = 12, ∗p &lt; 0.001; ΔGluA1A2, 5.7 ± 1.4%, n = 24, ∗p &lt; 0.001; ΔGluA1A2A3, 2.4 ± 0.6%, n = 13, ∗p &lt; 0.001).</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">(E) Models for AMPAR compositions at synaptic and extrasynaptic membranes. At CA1 pyramidal neurons, ∼80% synaptic AMPARs are GluA1A2 heteromers, and ∼16% synaptic AMPARs are GluA2A3 heteromers. On the other hand, ∼95% extrasynaptic AMPARs are GluA1A2 heteromers.</ins></div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">[[Category:Synaptic Plasticity]] [[Category:Journals]]</ins></div></td></tr> </table>

Bradley Monk https://bradleymonk.com/wiki/index.php?title=File:Lu_Nicoll_2009_FIG6.jpg&diff=2741&oldid=prev 2015-03-21T02:05:40Z

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