https://bradleymonk.com/wiki/index.php?action=history&feed=atom&title=File%3ALu_Nicoll_2009_FIG5.jpg 2026-04-09T17:10:13Z Revision history for this page on the wiki MediaWiki 1.41.0 https://bradleymonk.com/wiki/index.php?title=File:Lu_Nicoll_2009_FIG5.jpg&diff=2754&oldid=prev 2015-03-21T02:12:01Z

<p></p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 19:12, 20 March 2015</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l8">Line 8:</td> <td colspan="2" class="diff-lineno">Line 8:</td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>(A–E) The recordings were made from acute hippocampal slices (P20–P27) from animals injected at P0–P1.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>(A–E) The recordings were made from acute hippocampal slices (P20–P27) from animals injected at P0–P1.</div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>[[Category:Synaptic Plasticity]] [[Category:Journals]]</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>[[Category:Synaptic Plasticity]] [[Category:Journals<ins style="font-weight: bold; text-decoration: none;">]][[Category:Nicoll</ins>]]</div></td></tr> </table>

Bradley Monk https://bradleymonk.com/wiki/index.php?title=File:Lu_Nicoll_2009_FIG5.jpg&diff=2745&oldid=prev 2015-03-21T02:07:16Z

<p></p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 19:07, 20 March 2015</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l1">Line 1:</td> <td colspan="2" class="diff-lineno">Line 1:</td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">{{Article|Lu, Shi, Nicoll|2009|Cell - [http://www.sciencedirect.com/science/article/pii/S0896627309002554 FullText]|19409270|Subunit composition of synaptic AMPA receptors revealed by a single-cell genetic approach}}</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">; Figure 5. </ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">Deletion of GluA2A3, GluA1A3, or GluA1A2 in CA1 Pyramidal Cells</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">(A) (A1–A5) Scatter plots (A1–A3) and bar graphs (A4 and A5) show amplitudes of EPSCs for single pairs (open circles) and mean ± SEM (filled circles) for GRIA2A3fl/fl (A1), GRIA1A3fl/fl (A2), and GRIA1A2fl/fl (A3), respectively. (A4) The amplitudes of AMPAR EPSCs were significantly reduced in all three cases (ΔGluA2A3, Cnt, −58.1 ± 11.4 pA; Cre, −24.9 ± 3.3 pA; n = 14; ∗p &lt; 0.01; ΔGluA1A3, Cnt, −128.4 ± 19.7 pA; Cre, −15.6 ± 3.10 pA; n = 12; ∗p &lt; 0.001; ΔGluA1A2, Cnt, −84.3 ± 10.1 pA; Cre, −4.9 ± 0.8 pA; n = 24; ∗p &lt; 0.001). (A5) No change in the size of NMDAR EPSCs was observed (ΔGluA2A3, Cnt, 40.3 ± 7.4 pA; Cre, 38.0 ± 6.3 pA, n = 12; p = 0.82; ΔGluA1A3, Cnt, 49.2 ± 11.7 pA; Cre, 49.0 ± 13.7 pA, n = 11; p = 0.99; ΔGluA1A2; Cnt, 36.3 ± 5.8 pA; Cre, 31.0 ± 4.2 pA, n = 23; p = 0.31). (Inset in A1–A3) Sample traces are as follows: black, control; green, Cre.</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">(B and C) Bar graphs show average RI (B) (Cnt, 0.99 ± 0.03, n = 30; ΔGluA2A3, 0.14 ± 0.02, n = 13; ∗p &lt; 0.001; ΔGluA1A3, 1.06 ± 0.2, n = 5; p = 0.59; ΔGluA1A2, 0.1 ± 0.02, n = 6; ∗p &lt; 0.001) and average PPR (C) (Cnt, n = 84; ΔGluA2A3, n = 14; ΔGluA1A3, n = 6; ΔGluA1A2, n = 11; p &gt; 0.05 for each conditions). Left were sample traces. For GRIA1A2fl/fl cells, the stimulus was increased to record measurable EPSCs, and only recordings from the Cre cell were shown.</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">(D) Sample recordings of mEPSCs at low gain and sweep speed (traces on left; scale bar, 10 pA, 500 ms) and averaged mEPSCs at high gain and sweep speed (traces on right). Control trace (black) has been superimposed on the trace from a Cre cell. Scale bar, 5 pA, 10 ms.</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">(E) (E1) Bar graphs show mEPSC amplitude (top, Cnt, −10.51 ± 0.37 pA; ΔGluA2A3, −10.56 ± 0.60 pA; p = 0.93; ΔGluA1A3, −7.21 ± 0.36 pA; ∗p &lt; 0.001; ΔGluA1A2, −6.79 ± 0.20 pA; ∗p &lt; 0.001), (E2) frequency (middle, Cnt, 0.28 ± 0.03 Hz; ΔGluA2A3, 0.17 ± 0.05 Hz; ∗p &lt; 0.005; ΔGluA1A3, 0.03 ± 0.01 Hz; ∗p &lt; 0.001; ΔGluA1A2, 0.06 ± 0.01 Hz, ∗p &lt; 0.001), and (E3) decay (bottom, Cnt, 11.30 ± 0.49 ms; ΔGluA2A3, 10.18 ± 1.2 ms; p = 0.33; ΔGluA1A3, 14.70 ± 0.71 ms; ∗p &lt; 0.01; ΔGluA1A2, 4.20 ± 0.71 ms; ∗p &lt; 0.001). n = 22, 14, 7, and 9 for Cnt, ΔGluA2A3, ΔGluA1A3, and ΔGluA1A2, respectively.</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">(A–E) The recordings were made from acute hippocampal slices (P20–P27) from animals injected at P0–P1.</ins></div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">[[Category:Synaptic Plasticity]] [[Category:Journals]]</ins></div></td></tr> </table>

Bradley Monk https://bradleymonk.com/wiki/index.php?title=File:Lu_Nicoll_2009_FIG5.jpg&diff=2738&oldid=prev 2015-03-21T02:05:09Z

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