https://bradleymonk.com/wiki/index.php?action=history&feed=atom&title=File%3ALu_Nicoll_2009_FIG4.jpg 2026-04-09T17:10:13Z Revision history for this page on the wiki MediaWiki 1.41.0 https://bradleymonk.com/wiki/index.php?title=File:Lu_Nicoll_2009_FIG4.jpg&diff=2753&oldid=prev 2015-03-21T02:11:56Z

<p></p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 19:11, 20 March 2015</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l8">Line 8:</td> <td colspan="2" class="diff-lineno">Line 8:</td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>(F) (F1) Bar graphs show mEPSCs amplitude (Cnt, −10.51 ± 0.37 pA; ΔGluA2, 11.08 ± 0.65 pA; p = 0.42), (F2) frequency (Cnt, 0.28 ± 0.03 Hz; ΔGluA2, 0.16 ± 0.03 Hz; ∗p &lt; 0.001), and (F3) decay (Cnt, 11.30 ± 0.49 ms; ΔGluA2, 9.75 ± 1.14 ms; p = 0.27). n = 22 and 17 for Cnt and ΔGluA2, respectively.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>(F) (F1) Bar graphs show mEPSCs amplitude (Cnt, −10.51 ± 0.37 pA; ΔGluA2, 11.08 ± 0.65 pA; p = 0.42), (F2) frequency (Cnt, 0.28 ± 0.03 Hz; ΔGluA2, 0.16 ± 0.03 Hz; ∗p &lt; 0.001), and (F3) decay (Cnt, 11.30 ± 0.49 ms; ΔGluA2, 9.75 ± 1.14 ms; p = 0.27). n = 22 and 17 for Cnt and ΔGluA2, respectively.</div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>[[Category:Synaptic Plasticity]] [[Category:Journals]]</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>[[Category:Synaptic Plasticity]] [[Category:Journals<ins style="font-weight: bold; text-decoration: none;">]][[Category:Nicoll</ins>]]</div></td></tr> </table>

Bradley Monk https://bradleymonk.com/wiki/index.php?title=File:Lu_Nicoll_2009_FIG4.jpg&diff=2744&oldid=prev 2015-03-21T02:07:07Z

<p></p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 19:07, 20 March 2015</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l1">Line 1:</td> <td colspan="2" class="diff-lineno">Line 1:</td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">{{Article|Lu, Shi, Nicoll|2009|Cell - [http://www.sciencedirect.com/science/article/pii/S0896627309002554 FullText]|19409270|Subunit composition of synaptic AMPA receptors revealed by a single-cell genetic approach}}</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">; Figure 4. </ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">AMPARs Adjust Rapidly to the Deletion of GluA2</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">(A) (A1 and A2) The time course for the changes in synaptic transmission in hippocampal slice cultures from GRIA2fl/fl mice after transfection of Cre-IRES-GFP. Ratio of RI (open circles, 3–5 days, 0.95; 6 days, 0.99; 7–8 days, 0.71; 9–10 days, 0.60; 11–12 days, 0.34; 12–14 days, 0.16; &gt;14 days, 0.15), ratio of AMPAR EPSCs (closed circle, 3–5 days, 0.96; 6 days, 0.49; 7–8 days, 0.57; 9–10 days, 0.56; 11–12 days, 0.50; 12–14 days, 0.57; &gt;14 days, 0.51), and ratio of NMDAR EPSCs (closed diamonds, 3–5 days, 1.08; 6 days, 1.01; 7–8 days, 1.06; 9–10 days, 1.04; 11–12 days, 0.99; 12–14 days, 1.01; &gt;14 days, 1.10) from transfected cells to neighboring control cells, respectively. Open square shows RI from CA1 pyramidal neurons from germline GluA2 KO mice (0.13 ± 0.02, n = 5). (A2) Graph shows the percentage of the average AMPAR EPSCs (51.7% ± 5.2%; n = 86; ∗p &lt; 0.0001), NMDAR EPSCs (97.8% ± 13.2%; n = 64; p = 0.81), and RI (15.0% ± 1.8%; n = 19; ∗p &lt; 0.0001) from transfected cells or GluA2 KO cells (13.3% ± 2.0%; n = 5; ∗p &lt; 0.01) to control cells.</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">(B) (B1–B3) Scatter plots (B1) and bar graphs (B2 and B3) show amplitudes of EPSCs for single pairs (open circles) and mean ± SEM (filled circles) for GRIA2fl/fl. (Inset in B1) Sample traces are as follows: black, control; green, Cre. (B2) EPSC amplitudes show a significant reduction in the AMPAR EPSCs (Cnt, −66.2 ± 3.8 pA; Cre, −34.2 ± 2.5 pA; n = 86; ∗p &lt; 0.0001). (B3) There was no change in the NMDAR EPSCs (GluA2, Cnt, 40.0 ± 3.7 pA; Cre, 39.1 ± 3.4 pA, n = 64; p = 0.81). The data were pooled from acute hippocampal slices (P13–P17) from animals injected at P0–P2 and from hippocampal slice cultures.</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">(C and D) Bar graphs show average RI (C) (Cnt, 0.99 ± 0.03, n = 30; ΔGluA2, 0.15 ± 0.02, n = 19; ∗p &lt; 0.001) and average PPR (D) (Cnt, n = 84; ΔGluA2, n = 29; p &gt; 0.05). Left were sample traces.</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">(E) Sample traces of mEPSCs shown at a low gain and sweep speed (traces on left; scale bar, 10 pA, 500 ms) and averaged mEPSCs at a high gain and sweep speed (traces on right). Control trace (black) has been superimposed on the trace from a Cre cell. Scale bar, 5 pA, 10 ms. mEPSCs were recorded from acute hippocampal slices (P13–P18) from animals injected at P0–P2.</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">(F) (F1) Bar graphs show mEPSCs amplitude (Cnt, −10.51 ± 0.37 pA; ΔGluA2, 11.08 ± 0.65 pA; p = 0.42), (F2) frequency (Cnt, 0.28 ± 0.03 Hz; ΔGluA2, 0.16 ± 0.03 Hz; ∗p &lt; 0.001), and (F3) decay (Cnt, 11.30 ± 0.49 ms; ΔGluA2, 9.75 ± 1.14 ms; p = 0.27). n = 22 and 17 for Cnt and ΔGluA2, respectively.</ins></div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">[[Category:Synaptic Plasticity]] [[Category:Journals]]</ins></div></td></tr> </table>

Bradley Monk https://bradleymonk.com/wiki/index.php?title=File:Lu_Nicoll_2009_FIG4.jpg&diff=2737&oldid=prev 2015-03-21T02:04:44Z

<p></p> <p><b>New page</b></p><div></div>

Bradley Monk