https://bradleymonk.com/wiki/index.php?action=history&feed=atom&title=File%3ALu_Nicoll_2009_FIG3.jpg 2026-04-09T17:16:08Z Revision history for this page on the wiki MediaWiki 1.41.0 https://bradleymonk.com/wiki/index.php?title=File:Lu_Nicoll_2009_FIG3.jpg&diff=2752&oldid=prev 2015-03-21T02:11:51Z

<p></p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 19:11, 20 March 2015</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l8">Line 8:</td> <td colspan="2" class="diff-lineno">Line 8:</td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>(F) (F1) Bar graphs show mEPSC amplitude (Cnt, −10.5 ± 0.4 pA; ΔGluA1, −7.9 ± 0.5 pA; ∗p &lt; 0.001; ΔGluA3, −10.7 ± 0.1 pA; p = 0.77), (F2) frequency (Cnt, 0.28 ± 0.03 Hz; ΔGluA1, 0.08 ± 0.01 Hz; p∗ &lt; 0.001; ΔGluA3, 0.27 ± 0.05 Hz, p = 0.68), and (F3) decay (Cnt, 11.30 ± 0.49 ms; ΔGluA1, 7.73 ± 1.41 ms; ∗p &lt; 0.01; ΔGluA3, 11.60 ± 1.20 ms; p = 0.81). n = 22, 10, and 20 for Cnt, ΔGluA1, and ΔGluA3, respectively.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>(F) (F1) Bar graphs show mEPSC amplitude (Cnt, −10.5 ± 0.4 pA; ΔGluA1, −7.9 ± 0.5 pA; ∗p &lt; 0.001; ΔGluA3, −10.7 ± 0.1 pA; p = 0.77), (F2) frequency (Cnt, 0.28 ± 0.03 Hz; ΔGluA1, 0.08 ± 0.01 Hz; p∗ &lt; 0.001; ΔGluA3, 0.27 ± 0.05 Hz, p = 0.68), and (F3) decay (Cnt, 11.30 ± 0.49 ms; ΔGluA1, 7.73 ± 1.41 ms; ∗p &lt; 0.01; ΔGluA3, 11.60 ± 1.20 ms; p = 0.81). n = 22, 10, and 20 for Cnt, ΔGluA1, and ΔGluA3, respectively.</div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>[[Category:Synaptic Plasticity]] [[Category:Journals]]</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>[[Category:Synaptic Plasticity]] [[Category:Journals<ins style="font-weight: bold; text-decoration: none;">]][[Category:Nicoll</ins>]]</div></td></tr> </table>

Bradley Monk https://bradleymonk.com/wiki/index.php?title=File:Lu_Nicoll_2009_FIG3.jpg&diff=2743&oldid=prev 2015-03-21T02:06:57Z

<p></p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 19:06, 20 March 2015</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l1">Line 1:</td> <td colspan="2" class="diff-lineno">Line 1:</td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">{{Article|Lu, Shi, Nicoll|2009|Cell - [http://www.sciencedirect.com/science/article/pii/S0896627309002554 FullText]|19409270|Subunit composition of synaptic AMPA receptors revealed by a single-cell genetic approach}}</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">; Figure 3. </ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">Excitatory Synaptic Transmission at CA1 Pyramidal Neurons Is Mediated Primarily by GluA1A2 Heteromers</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">(A) (A1 and A2) The time course for changes in AMPAR EPSCs in hippocampal slice cultures from GRIA1fl/fl mice after transfection of Cre-IRES-GFP. For ΔGluA1, shown are the ratio of AMPAR-EPSCs (closed circles, 3–5 days, 1.02; 6 days, 0.75; 7–8 days, 0.43; 9–10 days, 0.37; 11–12 days, 0.28; 12–14 days, 0.23; &gt;14 days, 0.21) and ratio of NMDAR-EPSCs (closed diamonds, 3–5 days, 0.98; 6 days, 1.15; 7–8 days, 1.11; 9–10 days, 1.11; 11–12 days, 1.16; 12–14 days, 0.92; &gt;14 days, 1.09) from transfected cells to neighboring control cells, respectively. (A2) Bar graph shows the percentage of AMPAR EPSCs (21.2% ± 3.1%; n = 15; ∗p &lt; 0.0001) and NMDAR EPSCs (104.8% ± 17.6%; n = 14; p = 0.53) to controls.</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">(B) (B1–B4) Scatter plots (B1 and B2) and bar graphs (B3 and B4) show amplitudes of EPSCs for single pairs (open circles) and mean ± SEM (filled circles) for GRIA1fl/fl (B1, pooled data from acute slices [P19–P24] from animals injected at P0–P2 and from hippocampal slice cultures) and GRIA3fl/fl (B2, data from acute slices [P20-P25] from animals injected at P0–P2), respectively. (Inset in B1 and B2) Sample traces are as follows: black, control; green, Cre. (B3) EPSC amplitudes show a significant reduction in AMPAR EPSCs for the deletion of either subunit (ΔGluA1, Cnt, −77.7 ± 12.7 pA; Cre, −15.1 ± 2.4 pA; n = 31, ∗p &lt; 0.0001; ΔGluA3, Cnt, −56.4 ± 6.0 pA; Cre, −47.2 ± 5.6 pA; n = 19; ∗p &lt; 0.05). (B4) There was no change in the NMDAR EPSCs (GluA1, Cnt, 40.0 ± 9.4 pA; Cre, 33.6 ± 6.9 pA, n = 29; p = 0.31; ΔGluA3, Cnt, 40.4 ± 7.7 pA; Cre, 39.0 ± 7.8 pA, n = 19; p = 0.97).</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">(C and D) Bar graphs show average RI (C) (Cnt, 0.99 ± 0.03, n = 30; ΔGluA1, 1.02 ± 0.08, n = 14; p = 0.63; ΔGluA3, 1.06 ± 0.04, n = 15; p = 0.15) and average paired-pulse ratio (PPR, [D]) (Cnt, n = 84; ΔGluA1, n = 40; ΔGluA3, n = 9; p &gt; 0.05 for both conditions). Left were sample traces.</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">(E) Sample traces of mEPSCs shown at a low gain and sweep speed (traces on left; scale bar, 10 pA, 500 ms) and averaged mEPSCs at a high gain and sweep speed (traces on right). Control trace (black) has been superimposed on the trace from a Cre cell. Scale bar, 5 pA, 10 ms. mEPSCs were recorded from acute hippocampal slices (P20–P27) from animals injected at P0–P2.</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">(F) (F1) Bar graphs show mEPSC amplitude (Cnt, −10.5 ± 0.4 pA; ΔGluA1, −7.9 ± 0.5 pA; ∗p &lt; 0.001; ΔGluA3, −10.7 ± 0.1 pA; p = 0.77), (F2) frequency (Cnt, 0.28 ± 0.03 Hz; ΔGluA1, 0.08 ± 0.01 Hz; p∗ &lt; 0.001; ΔGluA3, 0.27 ± 0.05 Hz, p = 0.68), and (F3) decay (Cnt, 11.30 ± 0.49 ms; ΔGluA1, 7.73 ± 1.41 ms; ∗p &lt; 0.01; ΔGluA3, 11.60 ± 1.20 ms; p = 0.81). n = 22, 10, and 20 for Cnt, ΔGluA1, and ΔGluA3, respectively.</ins></div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">[[Category:Synaptic Plasticity]] [[Category:Journals]]</ins></div></td></tr> </table>

Bradley Monk https://bradleymonk.com/wiki/index.php?title=File:Lu_Nicoll_2009_FIG3.jpg&diff=2740&oldid=prev 2015-03-21T02:05:29Z

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